Viruses & Toxins

"To gain a more quantitative measurement of the antibody binding affinities to guide our epitope mapping experiments, we turned to KinExA analysis, a method that measures equilibrium binding affinities of unmodified molecules in the solution phase."
Wang X. et. al. 2017. Fine epitope mapping of two antibodies neutralizing the bordetella adeynlate cyclase toxin. Biochemistry. 56 (9). pp 1324-1336

 Virus & Toxin References

  • Lou, Jianlong, et al. 2018. A single tri-epitopic antibody virtually recapitulated the potency of a combination of monoclonal antibodies in neutralization of botulinum neurotoxin serotype A. Toxins 10(2), 84. http://doi.org/10.3390/toxins10020084.
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  • Kusano-Arai 0., et al. 2016. Kinetic exclusion assay of monoclonal antibody affinity to the membrane protein Roundabout 1 displayed on baculovirus. Anal Biochem. 10.1016/j.ab.2016.04.004. https://www.ncbi.nlm.nih.gov/pubmed/2709506
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  • Nowakowski A., et al. 2002. Potent neutralization of botulinum neurotoxin by recombinant oligoclonal antibody. Proc Natl Acad Sci 99: 11346-11350. http://www.ncbi.nlm.nih.gov/pubmed/12177434