The Best Therapeutics Are Measured With KinExA^®

The only biosensor available that can accurately measure binding interactions from nM to fM. 

For over 25 years KinExA Technology has been used to detect & measure biological interactions in the most physiologically relevant conditions. 

Equilibrium Dissociation Constant (k_d)
Association Rate Constant (k_on)
Dissociation Rate Constant (k_off)
Concentration Immunoassay

KinExA instruments overcome the limit of detection and immobilization presented by other technologies

Experiments do not require a chip or other expensive consumables

Trusted Accuracy | Proven Reliability | Unrivaled Sensitivity

" By tailoring the KinExA to each studied antigen, we obtained apparent equilibrium dissociation constants (Kd values) spanning six orders of magnitude, from approximately 100 fM to 100 nM. " 
Bee C. et. al. 2012 Exploring the dynamic range of the kinetic exclusion assay in characterizing antigen-antibody interactions.
​PLOS ONE 7(4) ​http://www.ncbi.nlm.nih.gov/pubmed/22558410

" The kinetics of binding and affinity of the 4 chimeric clones to human IL-21 were determined using a kinetic exclusion assay (KinExA)...Among the four lead clones, 19E3 had the highest affinity to recombinant human IL-21 of 243 fM " 
Reena Varkey et. al. 2019 Discovery and characterization of potent IL-21 neutralizing antibodies via a novel alternating antigen immunization and humanization strategy. PLOS ONE  
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211236