Measuring Affinity & Kinetics: The essential guide to understanding KinExA technology & high-affinity binding
September 21-22, 2023
Boise, Idaho
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Measuring Affinity & Kinetics: The essential guide to understanding KinExA technology & high-affinity binding
The only biosensor available that can accurately measure binding interactions from nM to fM.
Equilibrium Dissociation Constant (Kd)
Association Rate Constant (Kon)
Dissociation Rate Constant (Koff)
Concentration Immunoassay
Association Rate Constant (Kon)
Dissociation Rate Constant (Koff)
Concentration Immunoassay
For over 25 years KinExA® Technology has been used to detect & measure biological interactions in the most physiologically relevant conditions.
KinExA instruments are easy to use and require no expensive consumables like chips, plates, or kits to run experiments.
If you are using SPR, BLI, or LSA, you need KinExA to identify and optimize your lead candidates. KinExA instruments overcome the limit of detection and immobilization presented by other technologies.
KinExA instruments are easy to use and require no expensive consumables like chips, plates, or kits to run experiments.
If you are using SPR, BLI, or LSA, you need KinExA to identify and optimize your lead candidates. KinExA instruments overcome the limit of detection and immobilization presented by other technologies.
Trusted Accuracy | Proven Reliability | Unrivaled Sensitivity
" By tailoring the KinExA to each studied antigen, we obtained apparent equilibrium dissociation constants (Kd values) spanning six orders of magnitude, from approximately 100 fM to 100 nM. "
Bee C. et. al. 2012 Exploring the dynamic range of the kinetic exclusion assay in characterizing antigen-antibody interactions.
PLOS ONE 7(4) http://www.ncbi.nlm.nih.gov/pubmed/22558410
Bee C. et. al. 2012 Exploring the dynamic range of the kinetic exclusion assay in characterizing antigen-antibody interactions.
PLOS ONE 7(4) http://www.ncbi.nlm.nih.gov/pubmed/22558410
" The kinetics of binding and affinity of the 4 chimeric clones to human IL-21 were determined using a kinetic exclusion assay (KinExA)...Among the four lead clones, 19E3 had the highest affinity to recombinant human IL-21 of 243 fM "
Reena Varkey et. al. 2019 Discovery and characterization of potent IL-21 neutralizing antibodies via a novel alternating antigen immunization and humanization strategy. PLOS ONE
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211236
Reena Varkey et. al. 2019 Discovery and characterization of potent IL-21 neutralizing antibodies via a novel alternating antigen immunization and humanization strategy. PLOS ONE
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211236
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