Solution-Phase Affinity & Kinetics
For over 25 years KinExA® Technology has been used to detect & measure biological interactions in the most physiological relevant conditions with precision. Industry leading accuracy and sensitivity into the femtomolar range make KinExA an integral part of the lead identification and optimization process. Single-click analysis using KinExA Pro software is the gold standard for accurate affinity and kinetics data.
Equilibrium Dissociation Constant (Kd) | Association Rate Constant (Kon) | Dissociation Rate Constant (Koff)
Concentration Immunoassay | Rapid PAH Detection
" By tailoring the KinExA to each studied antigen, we obtained apparent equilibrium dissociation constants (K(D) values) spanning six orders of magnitude, from approximately 100 fM to 100 nM. "
Bee C. et. al. 2012 Exploring the dynamic range of the kinetic exclusion assay in characterizing antigen-antibody interactions.
PLOS ONE 7(4) http://www.ncbi.nlm.nih.gov/pubmed/22558410
" The kinetics of binding and affinity of the 4 chimeric clones to human IL-21 were determined using a kinetic exclusion assay (KinExA)...Among the four lead clones, 19E3 had the highest affinity to recombinant human IL-21 of 243 fM "
Reena Varkey et. al. 2019 Discovery and characterization of potent IL-21 neutralizing antibodies via a novel alternating antigen immunization and humanization strategy. PLOS ONE
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211236
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